Basic Principles of Biological Electron Microscopy

Jacob Hoogenboom aims to invent, develop, and implement new techniques that cross the boundaries and limitations of existing microscopes in visualizing molecules, molecular functionality, and structural details. Most of his work centres around the combination of light and electron microscopy, physically integrated in a single instrument.

Arjen Jakobi combines X-ray crystallography and electron cryo-microscopy (cryo-EM) to study large molecular assemblies involved in selective autophagy. He's also interested in the technical challenges for image processing and sample preparation in cryo-EM and XFEL imaging, and develops computational methods with the aim to make the interpretation of high-resolution cryo-EM maps a more routine task.